Product Details
Catalog Number: GP10108
Applications: IHC
Type: Guinea Pig IgG
Immunogen: VEKQSTDSGAYSIGH
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Shipping: Frozen (Polar Packs)
Format A: Whole serum
Species Reactivity: Rat
Entrez: 5024
UniProt: P56373
RRID: AB_2283325
Downloads: Datasheet (pdf)
Product Sizes
| Size | List Price | Price | Cart |
|---|---|---|---|
| 100 ul | $395.00 | Add to Cart |
P2X3 is a subunit in the family of ion channels activated by extracellular ATP. It was cloned from rat dorsal root ganglia. P2X3 has two putative transmembrane domains with intracellular N- and C-termini. It can form homomeric channels and heteromeric channels with other members of the family. P2X3 is expressed in nociceptive sensory neurons.
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Supporting Products
| Name | Catalog # | Size |
|---|---|---|
| P2X3 Blocking Peptide | P10108 | 100 ug Blocking Peptide |
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- Product Publications
Product Publications
- Kuang-Yi Tseng, Hung-Chen Wang, Yi-Hsuan Wang, Miao-Pei Su, Kai-Feng Cheng, Kuang-I Cheng, and Lin-Li Chang. (2023). Peripheral Nerve Denervation in Streptozotocin-Induced Diabetic Rats Is Reduced by Cilostazol. Medicina, 59(3), 553. doi: 10.3390/medicina59030553
- Ouyang Chen, Qianru He, Qingjian Han, Kenta Furutani, Yun Gu, Maddie Olexa, and Ru-Rong Ji. (2022). Mechanisms and Treatments of Neuropathic Itch in a Mouse Model of Lymphoma. The Journal of Clinical Investigation.
- Zacnite Garcia. (2020). Investigating the Molecules, Cells, and Circuits for Aversive Taste Signaling. The University of Texas at San Antonio, Doctoral Dissertation.
- Lou Beaulieu-Laroche, Marine Christin, Annmarie Donoghue, Francina Agosti, Noosha Yousefpour, Hugues Petitjean, Albena Davidova, Craig Stanton, Uzair Khan, Connor Dietz, Elise Faure, Tarheen Fatima, Amanda MacPherson, Stephanie Mouchbahani-Constance, Daniel G. Bisson, Lisbet Haglund, Jean A. Ouellet, Laura S. Stone, Jonathan Samson, Mary-Jo Smith, Kjetil Ask, Alfredo Ribeiro-da-Silva, Rikard Blunck, Kate Poole, Emmanuel Bourinet, and Reza Sharif-Naeini. (2020). TACAN Is an Ion Channel Involved in Sensing Mechanical Pain. Cell. doi: 10.1016/j.cell.2020.01.033
- Van B. Lu, Juraj Rievaj, Elisabeth A. O’Flaherty, Christopher A. Smith, Ramona Pais, Luke A. Pattison, Gwen Tolhurst, Andrew B. Leiter, David C. Bulmer, Fiona M. Gribble & Frank Reimann (2019). Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons. Nature Communications volume 10, Article number: 1029
- Gabriele Stephan, Lumei Huang, Yong Tang, Sandra Vilotti, Elsa Fabbretti, Ye Yu, Wolfgang Nörenberg, Heike Franke, Flóra Göröncsér, Beáta Sperlágh, Anke Dopychai, Ralf Hausmann, Günther Schmalzing, Patrizia Rubini & Peter Illes. The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel. Nature Communications volume 9, Article number: 1354 (2018) doi:10.1038/s41467-018-03728-5
- Tanja Bele and Elsa Fabbretti. (2016). The scaffold protein CASK controls ATP release in sensory ganglia upon P2X3 receptor activation and is part of an ATP keeper complex. Journal of Neurochemistry, doi: 10.1111/jnc.13680
- Saman Rahbar, Wen Pan, Michael G. Jonz. (2016). Purinergic and Cholinergic Drugs Mediate Hyperventilation in Zebrafish: Evidence from a Novel Chemical Screen. PLOS One, doi: 10.1371/journal.pone.0154261
- Erina Ikeda, Tetsuya Goto, Kaori Gunjigake, Kayoko Kuroishi, Masae Ueda, Shinji Kataoka, Takashi Toyono, Mitsushiro Nakatomi, Yuji Seta, Chiaki Kitamura, Tatsuji Nishihara, Tatsuo Kawamoto. (2016). Expression of Vesicular Nucleotide Transporter in Rat Odontoblasts. ACTA HISTOCHEMICA ET CYTOCHEMICA, doi: 10.1267/ahc.15022
- Paulino Barragán-Iglesias, Hector I. Rocha-González, Jorge Baruch Pineda-Farias, Janet Murbartián, Beatriz Godínez-Chaparro, Peter S. Reinach, Thiago M. Cunha, Fernando Q. Cunha, Vinicio Granados-Soto. (2014). Inhibition of peripheral anion exchanger 3 decreases formalin-induced pain, European Journal of Pharmacology, doi: 10.1016/j.ejphar.2014.05.029
- Liron S. Durakua, Mehdi Hossaini, Barthold N. Schüttenhelm, b, Joan C. Holstege, Martijn Baas, Tom J.H. Ruigrok, Erik T. Walbeehm. (2013). Re-innervation patterns by peptidergic Substance-P, non-peptidergic P2X3, and myelinated NF-200 nerve fibers in epidermis and dermis of rats with neuropathic pain. Experimental Neurology, Volume 241, Pages 13–24. doi: 10.1016/j.expneurol.2012.11.029
- Gary Mo, Jennifer C. Peleshok, Chang-Qing Cao, Alfredo Ribeiro-da-Silva and Philippe Séguéla. (2012). Control of P2X3 channel function by metabotropic P2Y2 UTP receptors in primary sensory neurons. Molecular Pharmacology, doi: 10.1124/mol.112.082099
- Abeer W Saeed, Alfredo Ribeiro-da-Silva. (2012). Non-peptidergic primary afferents are presynaptic to neurokinin-1 receptor immunoreactive lamina I projection neurons in rat spinal cord. Molecular Pain, 8:64. doi: 10.1186/1744-8069-8-64
- Anna M.W. Taylora, Maria Osikowicza, Alfredo Ribeiro-da-Silva. (2012). Consequences of the ablation of nonpeptidergic afferents in an animal model of trigeminal neuropathic pain. PAIN, Volume 153, Issue 6, Pages 1311–1319. doi: 10.1016/j.pain.2012.03.023
- Ji Z-G , Ito S , Honjoh T , Ohta H , Ishizuka T , et al. (2012). Light-evoked Somatosensory Perception of Transgenic Rats That Express Channelrhodopsin-2 in Dorsal Root Ganglion Cells. PLoS ONE, 7(3): e32699. doi: 10.1371/journal.pone.0032699
- Gabriela Castañeda-Corral, Héctor I. Rocha-González, Beatriz Godínez-Chaparro, Juan Miguel Jiménez-Andrade and Vinicio Granados-Soto. (2011). Role of the spinal Na+/H+ exchanger in formalin-induced nociception. Neuroscience Letters, doi: 10.1016/j.neulet.2011.06.048
- Anna M.W. Taylora and Alfredo Ribeiro-da-Silva. (2011). GDNF levels in the lower lip skin in a rat model of trigeminal neuropathic pain: Implications for nonpeptidergic fiber reinnervation and parasympathetic sprouting. PAIN, Volume 152, Issue 7, Pages 1502-1510. doi: 10.1016/j.pain.2011.02.035
- Jennifer C. Peleshok, Alfredo Ribeiro-da-Silva. (2011). Delayed reinnervation by nonpeptidergic nociceptive afferents of the glabrous skin of the rat hindpaw in a neuropathic pain model. The Journal of Comparative Neurology, Volume 519, Issue 1, pages 49–63. doi: 10.1002/cne.22500
- C.K. Park, J.H. Bae, H.Y. Kim, H.J. Jo, Y.H. Kim, S.J. Jung, J.S. Kim, and S.B. Oh. (2010). Substance P Sensitizes P2X3 in Nociceptive Trigeminal Neurons. Journal of Dental Research, 89: 1154 - 1159. doi: 10.1177/0022034510377094
- James P. Lund,Somayeh Sadeghi,Tuija Athanassiadis, Nadia Caram Salas, François Auclair, Benoît Thivierge, Isabel Arsenault, Pierre Rompré, Karl-Gunnar Westberg, and Arlette Kolta. (2010). Assessment of the Potential Role of Muscle Spindle Mechanoreceptor Afferents in Chronic Muscle Pain in the Rat Masseter Muscle. PLoS One, 5(6): e11131. doi: 10.1371/journal.pone.0011131
- Marianna D'Arco, Rashid Giniatullin, Vanessa Leone, Paolo Carloni, Nicol Birsa, Asha Nair, Andrea Nistri, and Elsa Fabbretti. (2009). The C-terminal Src Inhibitory Kinase (Csk)-mediated Tyrosine Phosphorylation Is a Novel Molecular Mechanism to Limit P2X3 Receptor Function in Mouse Sensory Neurons J. Biol. Chem., 284: 21393 - 21401. doi: 10.1074/jbc.M109.023051
- Anna M.W. Taylor, Jennifer C. Peleshok, Alfredo Ribeiro-da-Silva. (2009). Distribution of P2X3-immunoreactive fibers in hairy and glabrous skin of the rat. Comp. Neurol., 514:555-566. doi: 10.1002/cne.22048
- Ruizhong Wang, Tamara King, Michael H Ossipov, Anthony J Rossomando, Todd W Vanderah, Pamela Harvey, Peter Cariani, Eric Frank, Dinah W Y Sah, Frank Porreca. (2008). Persistent restoration of sensory function by immediate or delayed systemic artemin after dorsal root injury. Nat Neurosci, doi: 10.1038/nn2069
- Min Liu, Wenlong Huang, Dongsheng Wu and John V. Priestley. (2006). TRPV1, but not P2X3, requires cholesterol for its function and membrane expression in rat nociceptors. European Journal of Neuroscience, Volume 24 Page 1. doi: 10.1111/j.1460-9568.2006.04889.x
- Carole Torsney, Rebecca L Anderson, Kerry-Anne G Ryce-Paul, and Amy B MacDermott. (2006). Characterization of sensory neuron subpopulations selectively expressing green fluorescent protein in phosphodiesterase 1C BAC transgenic mice Mol Pain, 2: 17. doi: 10.1186/1744-8069-2-17
- Averill S, Michael G, Shortland P, Leavesley R, King V, Bradbury E, McMahon S, and Priestley J. (2004). NGF and GDNF ameliorate the increase in ATF3 expression which occurs in dorsal root ganglion cells in response to peripheral nerve injury. Eur. J. Neurosci., 19(6):1437-1445. doi: 10.1111/j.1460-9568.2004.03241.x
- Averill S, Davis DR, Shortland PJ, Priestley JV, Hunt SP. (2002). Dynamic Pattern of Reg-2 Expression in Rat Sensory Neurons after Peripheral Nerve Injury. J. Neurosci., 22(17):7493-7501.
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Images
Non-petidergic fibers expressing P2X3 receptor for ATP are present in lamina II of the contralateral dorsal horn (arrows). The P2X3-positive fibers are eliminated from the rat dorsal horn ipsilateral to the rhizotomy (arrow heads). Spinal cord segment C6. Scale bar 400 um. P2X3 antibody dilution 1:25,000. Biomédica vol.24 no.2
Non-petidergic fibers expressing P2X3 receptor for ATP are present in lamina II of the contralateral dorsal horn (arrows). The P2X3-positive fibers are eliminated from the rat dorsal horn ipsilateral to the rhizotomy (arrow heads). Spinal cord segment C6. Scale bar 400 um. P2X3 antibody dilution 1:25,000. Biomédica vol.24 no.2
P2X3 staining in rat DRG
P2X3 staining in rat DRG