Product Details
Product Sizes
| Size | List Price | Price | Cart |
|---|---|---|---|
| 12 well | $3,744.00 | $3,182.40 | Add to Cart |
| 24 well | $5,220.00 | $4,437.00 | Add to Cart |
| 6 well | $2,563.20 | $2,178.72 | Add to Cart |
Human BBB is available only to US customers Our model mimic transport properties of the Blood Brain Barrier (BBB) due to the formation of tight junctions, higher expression of specific carriers, or great cell viability. We developed a 3D in vitro model of the BBB by culturing brain endothelial cells with pericytes and astrocytes layered in an insert. This model improves endothelial cell polarization and enhances the formation of tight junctions, provide better endothelial cell-to-cell contact that is important for barrier development, and prevent the dilution of secreted neurotrophic factors, and these conditions collectively led to the development of an in vitro model that can truly mimic the BBB. Models are made to order. Please allow 4-8 weeks for completion. Models come with media. Additional media can be ordered (catalog # NMBBB01). BBB model can be used for transport and permeability studies from ions to macromolecules. Models are prepared and manufactured in an ISO 9001:2015 certified environment and ISO 5 cleanroom. Product Highlights: |
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- Product Publications
Product Publications
- Mahmoud Elashiry, Angelica Carroll, Jessie Yuan, Yutao Liu, Mark Hamrick, Christopher W. Cutler, Qin Wang, and Ranya Elsayed. (2024). Oral Microbially-Induced Small Extracellular Vesicles Cross the Blood–Brain Barrier. International Journal of Molecular Sciences, 25(8), 4509. doi: 10.3390/ijms25084509
- Tigerwin Yang and Ranya Elsayed. (2024). Periodontitis Gingival Tissue Exosomes Cross and Compromise Human BBB in an In-Vitro 3D Model. Dentistry Review, 4(3), 100114. doi: 10.1016/j.dentre.2024.100114
- Sookhee Bang, Jeong Kuen Song, Seung-Wook Shin, and Kwan Hee Lee. (2021). Human Serum Albumin Fusion Protein as Therapeutics for Targeting Amyloid Beta in Alzheimer’s Diseases. Neuroscience Letters. doi; 10.1016/j.neulet.2021.136298
Product Patent Application
- Sookhee Bang, Jeong Kuen Song, Seung-wook Shin, Kwan Hee Lee, and Ho June Lee. (2020). Method of Treating Central Nervous System Disease. United States Patent Application 20200230218
If you've used this product in a publication, let us know. Email pshuster@neuromics.com, with the publication details and you could be eligible for an Amazon gift card.
- Related Products
Related Products
Name Catalog # Size 3D HUVEC Model 3D45001 12 well 3D HUVEC Model 3D45001 24 well 3D HUVEC Model 3D45001 6 well Human BBB Model Media NMBBB01 500 ml - Media
Images
ACE-2 staining (red) and DAPI nuclear counterstain (blue) of the endothelial cells on the bottom of the inserts. Images collected on a microscope.
ACE-2 staining (red) and DAPI nuclear counterstain (blue) of the endothelial cells on the bottom of the inserts. Images collected on a microscope.
Diagram of BBB Model Insert
Diagram of BBB Model Insert
A demonstration of how to measure TEER. Shown using a control plate.