Transcription factors are involved in gene regulation, turning on and off the expression of certain genes in cells. Their DNA-binding domains allow them to bind to specific sequences of DNA, a distinct feature. By regulating the expression of genes in different cell types and during development, transcription factors direct cell division, cell growth, and cell death. Our selection of transcription factor antibodies includes antibodies in the following family: FOX, HIFs, SOX, and bHLH.
- FOX
FOX or Forkhead box Proteins are a family of transcriptional regulators that are defined by a conserved 100-amino acid DNA-binding domain. They regulate diverse cellular processes including differentiation, metabolism, development, proliferation, and apoptosis. Many are involved in embyrogensis and organogenesis. This includes the regulation of stem cells and progenitors.
The misregulation and/or mutation of FOX genes often induce human genetic diseases, promote cancer or deregulate ageing. Indeed, germinal FOX gene mutations cause diseases ranging from infertility to language and/or speech disorders and immunological defects.
Name Catalog # Type Species Applications Size Price FOXC1 GT41004 Goat IgG Human, Mouse WB, IHC 100 ug $365.00 FOXE1 GT41017 Goat IgG Human IHC, E 100 ug $365.00 FOXN1 GT41016 Goat IgG Human IHC, E 100 ug $365.00 FOXP2 GT41022 Goat IgG Human, Rat WB, IHC 100 ug $365.00 FOXP3/Scurfin GT41002 Goat IgG Human IHC 100 ug $365.00 - HIFs
Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease
HIFs (Hypoxia-inducible factors) respond to changes in available oxygen, especially hypoxia. They are critical for mainting oxygen homeostasis and preventing hypoxia. They are also vital to development. In mammals, deletion of the HIF-1 genes results in perinatal death. HIF-1 has been shown to be vital to chondrocyte survival, allowing the cells to adapt to low-oxygen conditions within the growth plates of bones.
Name Catalog # Type Species Applications Size Price Factor Inhibiting HIF-1/FIH RA25046 Rabbit IgG Mouse, Rat ICC, WB, IHC 100 ul $379.00 HIF Prolyl Hydroxylase 2 MO25046 Mouse IgG Human WB, IHC 100 ul $379.00 HIF-1 alpha RA25066 Rabbit IgG Human, Primate WB 100 ul $379.00 HIF-2 alpha Biotin MO25044B Mouse IgG Human, Mouse, Rat WB, IHC 100 ul $529.00 - SOX
The developmentally important Sox family has no singular function, and many members possess the ability to regulate several different aspects of development. While many Sox genes are involved in sex determination, some are also important in processes such as neuronal development. For example, Sox2 and Sox3 are involved in the transition between epithelial granule cells in the cerebellum to their migratory state. Granule cells then differentiate to granule neurons, with Sox11 being involved in this process. It is thought that some Sox genes may be useful in the early diagnosis of childhood brain tumours due to this sequential expression in the cerebellum, making them a target for significant research
Name Catalog # Type Species Applications Size Price SOX-10 MO47006 Mouse IgG Human WB, IHC 100 ug $309.00 SOX-2/SRY (sex determining region Y)-box 2 MO47038 Mouse IgG Human IHC 100 ul $309.00 SOX2 RA25021 Rabbit IgG Human, Mouse ICC, WB, IHC 100 ul $379.00 SRY (Sex Determining Region Y)-Box 11/SOX-11 MO47052 Mouse IgG Human IHC 100 ul $309.00 - bHLH
Basic Helix-Loop-Helix (bHLH) transcription factors are important in the development of cell activity.
Name Catalog # Type Species Applications Size Price MiTF (Microphthalmia-Associated Transcription Factor) MO47034 Mouse IgG Human IHC 0.5 ml $309.00 Myogenin (Myogenic Factor 4)/MYOG MO47054 Mouse IgG Human IHC 100 ul $309.00 Transcription Factor E3 (TFE3) MO47007 Mouse IgG Human WB, IHC 100 ul $309.00