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Neuromics has a large selection of human cells for cancer research. These cells have been used in impactful and meaningful studies by customers - check all the studies out here. At the center of the selection are our cancer associated fibroblasts (CAFs). Collaborating investigators from Takeda, BioTuring, and BMS utilized our Pancreatic CAFs (cat. CAF118) and CAF Growth Media (cat. CAFM03) in a study released earlier this month.

It is widely accepted that CAFs play a vital role in the tumor microenvironment (TME) and are a frequent target for therapeutics. However, despite successful results in 2D culture, many drug candidates struggle when tested in clinical trials.

Image: Gene expression profile of Neuromics Pancreatic CAFs and BxPC3 cells in 2D and 3D monocultures and cocultures. Different culture conditions lead to changing expression profiles.

In the publication, the investigators examined various culture conditions for CAFs, including 2D and 3D monocultures and cocultures. They found that the expression profile and pro-proliferative effects of CAFs vary substantially depending on the culture condition.

The CAFs show their full potential in the TME when cultured in 3D tumor models. The results suggest that drug discovery research should implement 3D models to get a better-predicted outcome when evaluating drug candidates than 2D culture. Read the full study here.

How is Neuromics planning on celebrating the holidays? By offering an unbeatable deal on fetal bovine serum (FBS) that you won't want to miss.

Through the end of the year, Neuromics is offering our Preferred FBS (cat. FBS007) for only $199/500 ml. It's not very often that you can get FBS for under $200 per bottle. Furthermore, the heat inactivated version (cat. FBS007-HI) is available at $204/500 ml.

Preferred FBS offers an elite combination of quality and price. We are confident in its ability to culture most cell types and encourage all our FBS customers to give it a shot. However, if you are working with more sensitive cell types or need specialty FBS for your application, we always have further options available.

Neuromics FBS continues to excel for investigators in their research. It is frequently cited in publications - read them all here. For example, last week, Korean scientists published a study using our Premium US Origin FBS (cat. FBS001) to culture mixed rat cortical cells in stroke research.

For the past couple of months, Neuromics has been promoting 15% off all human cells through the end of the year. However, all good things must come to an end. Fortunately, you can still take advantage of the sale throughout December.

Our human cell offerings feature key primary cells, iPSC-derived cells, and cell lines with applications abound. These cells have been used in impactful and prominent neuroscience, cancer, diabetes, and COVID-19 research, just to name a sampling.

Image: ACE-2 staining (red) and DAPI nuclear counterstain (blue) of the endothelial cells (cat. HEC02) on the bottom of the inserts of our 3D human BBB model (cat. 3D45002).

Please contact us if you have any questions about any of our cells. You can also explore all our human cells here. Lastly, check out the many customer publications here.

Check out the video below to learn more about the promotion and how you can save.

Our human endothelial cells have always been a particularly versatile tool for researchers. They have been used by neuroscientists to study the blood-brain barrier, diabetes researchers to study diabetic retinopathy, cancer researchers to study tumors, and much more. This week, another study was published using one of our many (see for yourself) types of endothelial cells. You can explore all publications using our endothelial cells here.

Image: A comparison of young and senescent HBMECs looking at DNA damage by staining with DAPI (top), numbers of actin stress fibers (middle), and CD31 expression (bottom)

Our human brain microvascular endothelial cells (HBMECs) (cat. HEC02) were used by scientists at the University of Nottingham in a paper published earlier this week. In the study, the investigators grew our HBMECs until they became senescent with implications in vascular aging and other age-related diseases. They tested our cells to see if they could find any reliable biomarkers for vascular aging by looking at the senescent cells. They noted morphological and functional changes in the HBMECs as the passage number increased. Learn more here.

In the past couple of weeks, our blog has shared studies using Neuromics GFP-expressing cells and cell lines in exciting research. Now, we are happy to highlight another new publication that merges the two—a GFP-expressing cell line. Last month, researchers at Dartmouth published a paper using our GFP-expressing human glioblastoma cells (U87 MG) (cat. TR01-GFP) in fluorescent-guided surgery research. 

Contrast imaging has become a frequently used tool in surgical resection so that surgeons can remove all tumor tissue when operating on patients. This method has especially become prevalent in glioma removal. While many methods for fluorescent-guidance surgery exist, the investigators wanted to look for one that accurately marks tumors shortly after administration and is compatible with current imaging capabilities.

Image: Imaging of mice inoculated with GFP expressing U87 MG cells after 40 and 90 minutes. A comparison with GFP shows how candidate fluorescent agents perform.